Open Access Open Access  Restricted Access Subscription Access
Total views : 84

A Randomised, Comparative Study to Evaluate the Efficacy and Tolerability of Two Fixed Dose Combinations of Camylofin & Mefenamic Acid and Dicyclomine & Mefenamic Acid in the Management of Primary Dysmenorrhea

Affiliations

  • Sakthi Hospital & Research Centre, India
  • Abbott Healthcare Pvt Ltd, India

Abstract


Primary dysmenorrhea (PD) is a common gynaecological disorder affecting nearly 50% of menstruating women. Camylofin combination with paracetamol has demonstrated superior efficacy than dicyclomine- paracetamol combination, in the treatment of colicky abdominal pain. However, comparative data on these two antispasmodics in combination with Mefenamic acid in PD is not available.

Aim: To compare the efficacy and tolerability of fixed dose combinations of Camylofin + Mefenamic acid and Dicyclomine + Mefenamic acid in patients with Primary Dysmenorrhea.

Methods: A randomised, open-label, comparative study, to evaluate the efficacy and tolerability of a fixed-dose combination of Camylofin 50 mg + Mefenamic acid 250 mg (Study Group) and Dicyclomine 10 mg + Mefenamic acid 250 mg (Control Group) in 50 PD patients.

Results: In the study group (Camylofin + Mefenamic Acid) the VAS scores reduced by 86% and 100% on day 3 and day 5 respectively as compared to a marginally less decrease in VAS scores by 82% and 95% on day 3 and day 5 respectively in the control group(P>0.05). Patients with complete pain relief (study end) were almost 96% and 88% patients in the study and control groups respectively (P>0.05). Global assessment of efficacy by the investigator showed that 73% of the patients in the study group were rated as 'Very Good' to 'Excellent' as compared to 54% of the patients in the control group (P>0.05).

Conclusion: These findings suggest that Camylofin + Mefenamic acid may be a better alternative to Dicyclomine + Mefenamic acid. However, the results did not attain statistical significance.


Full Text:

 |  (PDF views: 2)

References


  • Ramya Sugumar, Vasundara Krishnaiah et al. Comparison of the pattern, efficacy, and tolerability of self medicated drugs in primary dysmenorrhea: A questionnaire based survey. Indian J Pharmacol. 2013 MarApr; 45(2): 180–183.
  • Marjoribanks J, Proctor M et al.Nonsteroidal antiinflammatory drugs for dysmenorrhoea. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD001751
  • V. G. Padubidri, Shirish N Daftary. Shaw’s Textbook of Gynecology. Elsevier Health Sciences. 2014; 472-473
  • Kamini. A. Rao. Textbook Of Gynaecology. Elsevier India, 2009; 42-43
  • Warke H, Chauhan A, Raut V, Ingle KM. Efficacy of camylofin dihydrochloride in acceleration of labour: A randomised double blind trial. Bombay Hospital Journal 2003; 45(3): 420–3
  • C Gupta. Drug Trial Report-Use of Anafortan intravenous injection for treatment of colicky pain. J Indian Med Assoc. 98(8):497-482
  • Mohd Ali, Manoj Naik et al. Open,randomized comparative study to evaluate efficacy, safety and tolerability of Anafortan Vs. dicyclomine+paracetamol in treatment of mild to moderate abdominal colic and spasmodic abdominal pain. Indian Medical Gazette.2010: 314-321
  • Lefebvre G, Pinsonneault O et al. Primary dysmenorrhea consensus guideline. J Obstet Gynaecol Can. 2005 Dec;27(12):1117-46.
  • Dabholkar KM. Mefenamic acid with dicyclomine is a highly effective and well tolerated treatment for spasmodic dysmenorrhea. The Indian Practitioner. 1999 Nov; 52(11): 767
  • Rajani U, Binu P. A Randomized Comparative Study of Intramuscular Camylofin Dihydrochloride and Intravenous Drotaverine Hydrochloride on Cervical Dilatation in Labor. Indian Journal of Clinical Practice. 2015; 26(6):558-563
  • Shridhar S. Dayama, Sunil S. Patil et al. A Randomised Controlled Study of Intramuscular Camylofin Dihydrochloride vs Intravenous Hyoscine Butylbromide in Augmentation of Labour. Global Journal of Medical Research: E Gynecology and Obstetrics. 2016; 16(1)
  • K Sarbhjit, Bawja K. To Compare the Effect of Camylofin Dihydrochloride (Anafortin) with Combination of Valethamate Bromide (Epidosin) and Hyoscine ButylN-Bormide (Buscopan) on Cervical Dilation. Journal of Clinical and Diagnostic Research. 2013 Sept, 7(9): 1897-1899

Refbacks

  • There are currently no refbacks.