Open Access Subscription AccessTotal views : 54
Plasmodium Vivax Malaria with Common & Carotid Artery Thrombosis & Antiphospolipid Antibody Syndrome – An Unusual Presentation
In recent years, the association between infection&anti-phospholipid antibody syndrome have been reported in several epidemiologic&experimental studies that support the idea of infectious induction of Anti-phospholipid Syndrome.(1)(2) Herein we report 72 yr premorbidly healthy male presented with P.vivax malaria with multi-organ dysfunction syndrome with ARDS. On 6th day of admission, he developed left side hemiplegia. MRI+MRA (BRAIN) showed Right ACA territory infarct&thrombosed right common&internal carotid artery thrombosis. Autoimmune work-up showed ACLA IgM; APLA IgM; β2-glycoprotein-1 IgM were highly significant titre [58.9 MPL/ml,58.3 U/ml,113.9 RU/ml respectively]. Infections like malaria triggering Anti-phospholipid antibody Syndrome has been described in paediatric age groups. So Plasmodium vivax malaria with hepatic involvement with ARDS with common&internal carotid thrombosis due to secondary APLA Syndrome in geriatric age group is very unusual presentation. We managed this patient with anti-malarials, supportive therapy, anti-coagulation with heparin followed by warfarin overlap with PT/INR monitoring.
P.Vivax Malaria, Anti-Phospholipid Antibody Syndrome, Carotid Artery Thrombosis.
- Cervera R, Asherson RA, Acevedo ML. Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics of 100 patients. Ann Rheum Dis. 2004;63:1312-7.
- Avcin T, Toplak N. Antiphospholipid antibodies in response to infection. Curr Rheumatol Rep. 2007;9:212-8.
- Consigny PH, Cauquelin B, Agnamey P. High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals. Clin Exp Immunol. 2002;127:158-64.
- Tamaria KC, Agrawal S. Splenic infarction in P.vivax malaria. Journal of Indian Paed. 2013;50:886
- Sunil Taneja and Purvi Mittal. Splenic infarction in plasmodium vivax malaria INDIAN PEDIATRICS Volume 51; April 15;2014:320
- Facer CA, Agiostratidou G. High levels of antiphospholipid antibodies in uncomplicated and severe Plasmodium falciparum and in P. vivax malaria. Clin Exp Immunol. 1994;95(2):304–309.
- There are currently no refbacks.