Researchers at the Institute of Advanced Study in Science and Technology (IASST) in Guwahati, an autonomous institute under the Department of Science and Technology, have developed an innovative, cost-effective, and portable smartphone-based fluorescence turn-on sensor system to aid in the management of Parkinson’s disease.
The new sensor is designed to precisely measure L-dopa levels in the body, allowing for accurate adjustment of medication dosages for effective disease management. Parkinson’s disease is characterized by the progressive loss of neuron cells, which leads to a significant decrease in dopamine levels, a crucial neurotransmitter. L-dopa, a chemical that converts into dopamine, is commonly used as a treatment to counteract this deficiency.
Proper management of Parkinson’s disease requires maintaining an optimal level of L-dopa. If too little is administered, Parkinson’s symptoms may reappear, while excessive amounts can lead to severe side effects such as dyskinesia, gastritis, psychosis, paranoia, and orthostatic hypotension.
Given the importance of precise L-dopa levels for effective therapy, developing a simple, affordable, and rapid method for monitoring L-dopa in biological fluids is crucial. As reported by biospectrumindia.com, the new sensor utilizes a silk-fibroin protein nano-layer, derived from Bombyx mori silk cocoons, which is coated onto reduced graphene oxide nanoparticles, enhancing its sensitivity and usability.