A new study presented at the Annual Meeting of the Radiological Society of North America (RSNA) has revealed that diets high in ultra-processed foods are associated with increased intramuscular fat deposits in the thighs, potentially elevating the risk of knee osteoarthritis. The findings, based on MRI imaging of 666 participants from the Osteoarthritis Initiative, mark the first clear link between ultra-processed foods and fat replacing muscle in the thigh.
The study observed that these fat deposits occurred regardless of calorie intake or physical activity levels. The average age of participants was 60, and none had developed osteoarthritis at the time of the study.
Dr. Zehra Akkaya, the study’s lead author from Ankara University in Turkey, noted that MRI scans showed fatty degeneration of thigh muscles, where fat streaks replaced muscle fibers. This phenomenon has previously been linked to reduced knee function.
Experts, including those not involved in the study, highlighted the pro-inflammatory effects of ultra-processed foods, which include items like soda, packaged snacks, and processed meats. These foods often contain high levels of sugar, refined fats, and sodium, contributing to inflammation and insulin resistance.
“Osteoarthritis, the most common form of arthritis, often stems from chronic joint inflammation,” said Dr. Gowri Reddy Rocco, founder of Optimum Wellness and Longevity. She emphasized that thigh muscle degeneration weakens joints, increasing the likelihood of osteoarthritis progression.
Fortunately, experts noted that improving one’s diet could help regenerate muscle strength and slow joint damage, although existing cartilage loss cannot be reversed.
To prevent knee osteoarthritis, lifestyle factors such as maintaining a healthy weight, staying active, and avoiding ultra-processed foods are critical. Obesity, poor diet, and sedentary behavior are primary risk factors, while genetics and menopause can also play roles.
For those concerned about intramuscular thigh fat, diagnostic tools like skinfold tests, bioelectrical impedance analysis, and dual X-ray absorptiometry (iDXA) scans are available. However, experts stress that prevention through healthy eating and regular exercise remains the most effective strategy.
As reported by medicalnewstoday, the study’s findings are yet to be published in a peer-reviewed journal.