A large clinical study involving 1,500 eyes has confirmed that the latest generation of SMILE (Small Incision Lenticule Extraction) laser technology offers highly precise and safe results for correcting myopia and myopic astigmatism. Conducted at Nethradhama Super Speciality Eye Hospital, Bengaluru, the study used the VisuMax 800 femtosecond laser system and represents one of the world’s largest reported datasets for SMILE. ZEISS developed this second-generation laser platform in collaboration with Prof. Dr. Sri Ganesh, Chairman and Managing Director of Nethradhama.
High Accuracy and Rapid Recovery Demonstrated
Using retrospective data from 770 patients under 45 years of age, the study found that 98% of eyes achieved 20/20 or better unaided vision, and 99% were within ±0.50 diopters of the intended correction within 15 days of surgery. These outcomes highlight rapid visual recovery and strong refractive accuracy. Younger patients showed even faster recovery, and the procedure proved effective across all levels of myopia.
Nethradhama’s Pioneering Role in Global Clinical Research
Nethradhama was among the first five centres worldwide—and the first in India—to adopt the VisuMax 800 platform. The hospital also became the first institution to conduct global trials evaluating the system’s safety and efficacy.
> Dr. Supriya Samak Sriganesh, Executive Director of Nethradhama and co-author of the study, said the findings contribute valuable evidence to global ophthalmology research. She emphasized that by analysing outcomes across a diverse patient group, including long-term follow-ups, the study shows the sustained safety and effectiveness of the technology.
Reduced Surgical Risks with Advanced Laser Technology
As per the press release, the study also reported extremely low intraoperative risks. Suction loss occurred in only 0.06% of cases, a significant improvement compared to the 0.5% rates seen in earlier laser systems. This reduction highlights the enhanced safety profile of the VisuMax 800.
Transformational Technology Developed in India
Commenting on the technology, Prof. Dr. Sri Ganesh said the VisuMax 800 laser has transformed the efficiency of SMILE procedures. The system’s high-speed performance and automated alignment tools allow surgeons to complete laser steps in under 10 seconds while maintaining precision and safety.
> He added that AI-enabled nomograms and advanced centration and cyclotorsion control systems ensure highly predictable outcomes, making advanced vision correction more accessible and reliable.
AI-Enabled Guidance Enhances Surgical Accuracy
The VisuMax 800 integrates AI-enabled nomograms with centration guidance (CentraLign) and digital cyclotorsion control (OcuLign). These tools further strengthen accuracy and consistency during surgery, setting new global standards for refractive correction.
Setting New Global Benchmarks in Vision Correction
Prof. Dr. Ganesh stated that the platform elevates precision, patient safety, and surgical efficiency. The study reinforces SMILE as a global benchmark in laser vision correction. It also demonstrates how evidence-driven adoption of advanced technologies can shape the future of refractive surgery worldwide.
International Recognition for Scientific Leadership
Prof. Dr. Ganesh was recently recognized among the top 2% of researchers worldwide by Stanford-Elsevier (2025) for the second consecutive year. This recognition underscores his pioneering contributions and commitment to advancing global eye care.
Improved Patient Experience and Faster Recovery
The latest findings show that next-generation laser platforms significantly enhance accuracy, healing time, and overall patient comfort. The SMILE procedure is painless, uses only anaesthetic eye drops, and takes around 5–6 minutes for both eyes. Patients can walk in for treatment and walk out shortly after, often resuming daily activities by the next day.
Suitable for a Wide Range of Patients
The procedure is recommended for individuals above 18 years with stable short-sightedness or astigmatism for at least one year. Comprehensive screening—such as corneal topography and corneal thickness assessment—helps determine patient eligibility.
Global Adoption Continues to Grow
More than 13 million SMILE procedures have been performed worldwide, making it the fastest-growing refractive surgery option. Its rising popularity stems from its strong safety record, visual comfort, predictable outcomes, and proven long-term effectiveness.